If you get hit in either of the other 2 states you will not be teleported, The Black Candle item will remove the Cursed Eye's teleportation effect, REPENTANCE - Burst now has 5 shots instead of 4, * secret room pool, item room, treasure room, item room pool, white, circle, pearl, When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies for 1 damage per tick, * item room, treasure room, item room pool, mystery liquid, grey, gray, green, A familar that is attached to Isaac, which will seek out and damage any enemies close by for 3 contact damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, A familiar eye that follows Isaac and copies all his tear modifiers/effects, but shoots in random directions, Tears from this familiar deal 75% of Isaac's tear damage, UNLOCK: Unlock this item by beating Boss Rush with Cain, * item room, treasure room, item room pool, eyeball, white, circle, cataract, cains other eye, A familiar fly that can be moved around via use of the arrow keys dealing 2.5 contact damage per tick, similar to the Ludovico Technique's mechanic, UNLOCK: Unlock this item by beating Boss Rush with Blue Baby, * item room, treasure room, item room pool, blue fly, big fly, blue baby's only friend, fat, dead, ?? Holding the fire button charges a spin attack (Damage * 8 + 10). Toda. UNLOCK: Unlock this item by defeating Ultra Greed as Apollyon, At the start of each new hostile room, you have a 20% chance to gain a random charmed familiar which will fight for you, The charmed enemy has its own health bar and will die if it takes enough damage, Charmed enemies persist between each room and floor for as long as they stay alive, Allows you to have more than one charmed familiar at a time if you can keep them alive, * pokemon, phone, black, green, blue, gps, Every time one of your tears hits an enemy, it has a chance to start bleeding, which will cause it to take damage every 5 seconds, The bleed damage dealt by BackStabber is based on how quickly an enemy is moving (faster enemies take more damage), Damaging enemies from behind gives the bleed effect a 100% chance to apply, While an enemy bleeds, they leave behind creep that damages other enemies, The tear that inflicts the bleed effect also deals double damage, *, knife, dagger, red, heart, silver, knife, When used, Sharp Straw will deal damage to all enemies in the room, The damage dealt is equal to Isaac's current tear damage plus 10% of the enemy's max health, Every time this item deals damage, it has a 15% chance to drop 1/2 red hearts, REPENTANCE - Sharp Straw is now only able to generate half red hearts (previously, it generated half soul hearts if the player had no heart containers), A razor blade orbital that deals contact damage and applies the bleeding status effect to enemies and bosses, which will cause them to take damage every 5 seconds, The contact damage dealt by Mom's Razor is based on how quickly an enemy is moving (faster enemies take more damage), Its speed is not affected by the Guardian Angel item, An eye orbital that shoots tears that deal 3.5 damage and deals 2 contact damage per tick to enemies, The damage dealt by this orbital does not scale with damage upgrades, REPENTANCE - Bloodshot Eye now blocks enemy shots, has increased shot speed and rate of fire, and now only shoots when lined up with enemies, When used, spawns a charmed random white delirium version of a boss, that will fight for you and kill other enemies for the rest of the current room, Possible bosses spawned include most bosses in the game, Some bosses' effects can harm Isaac. Spawns coins as The Keeper, I can see forever - Opens secret room and super secret room entrances on the current floor, I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only), Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in it, Paralysis - Prevents you from moving for a short while, Pheromones - Applies the charm effect to all enemies in the room for a short while, Puberty - Causes Isaac to grow hair for the rest of the run. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. 4 keys = 50% chance. It can take you to rooms that require bombs/keys, e.g. Poison, Homing, Prize Bombs), In Antibirth this was called Enigma Bombs, Spawns a red worm familiar that chases enemies nearby around the room and deals 2 contact damage per tick. See the dedicated Devil room page for more details, First half of the key required to enter the door to the Mega Satan boss, Drops from one of the angels which appear by bombing the statue in an angel room, * angel room, angels, broken, yellow, gold, circle, Second half of the key required to enter the door to the Mega Satan boss, Randomly increases 4 of your stats, and decreases 2 of them, Possible stat changes are fixed values: 1 health, 1 damage, 0.2 speed, 0.5 range, 0.5 tears, 0.2 shot speed, 1 luck, UNLOCK: Unlock this item by beating Mom's Heart 7 times, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection, Doubles pickups and chests from clearing a room, Also gives a 30% chance for room clear rewards to not spawn, Doesn't affect coins spawned in Greed Mode, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, Here's the information about best items to unlock isaac People use search engines every day, but most people don't know some tricks that can help them get better search results, for example: when searching for "dog", "dog -black"(without quotation marks) can help you exclude search results that contain "black". Any item that unlocks Red Rooms is also a good one to prioritize for this reason, such as Soul of Cain (Boss Rush and Hush as Tainted Cain), Crystal Key (Mother as Tainted Lost), and Reverse Moon (Greedier as Tainted Jacob). Does not apply to locked chests, * item room, treasure room, item room pool, red, horse shoe, Reveals the entire map for every floor except the secret room locations, Does not show the icons for any unexplored rooms, Can still help you to guess which direction the boss room is in, due to the fact that the Boss Room is usually in the room furthest away from the first room, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, Be warned though, Mom's leg can also stomp and hurt Isaac too! All I could remember to prioritize was Revelation and Twisted Pair, so this helps. For Items it increases by 2 coins * the number of purchases. as Bethany, Gives you a random syringe effect every room, The effect can be The Virus, Roid Rage, Speed Ball, Experimental Treatment, Synthoil, Euthanasia or Growth Hormones, Placed bombs explode after 0.66 seconds instead of the usual 1.5 seconds, This was called Exploded Firecracker in Antibirth, Farts produced by Isaac or familiars will be twice as large, Chance for enemies to burn when entering a room, The chance for this effect to activate is effected by your Luck stat, This includes key blocks and golden chests, Pickups left on current floor will appear in the starting room of the next floor, up to a maximum of 4 pickups, Active items will be rerolled upon using them, Using with Book of Virtues will only reroll the item the book is holding, Has no effect with Notched Axe due to how its durability works, UNLOCK: Unlock this trinket by defeating Mother as Eden, Random luck-based tear effects have an extra chance of occurring, The additional chance is effectively +3 Luck Up, Picking up red hearts now has a high chance to spawn 1-4 blue attack spiders, instead of giving you health back, This effect also works while fully healed, giving a guaranteed chance of getting spiders, While missing any red health the chance for spiders is less, Works for characters that don't use red health, which always gives you spiders, Hearts in Shops can be converted into spiders for free, Gives your familiars improved rate of fire while held, In Antibirth this trinket was called Song of the Siren, UNLOCK: Unlock this trinket by bombing the skull left by The Siren boss after her death, While held at the start of each floor, this trinket spawns four wisp familiar orbitals around Isaac, These wisps are the same as the ones created by the Book of Virtues item, UNLOCK: Unlock this trinket by beating the Boss Rush as Bethany, Your active item no longer gains charges, but battery drops become much more common, UNLOCK: Unlock this trinket by blowing up 10 Battery Beggars, Tears that miss enemies will redirect themselves and travel 90 degrees towards enemies, Tears must be roughly 2 tiles or closer to activate this effect, +10 Luck while held, but the trinket is destroyed when damage is taken, Blood donation machines, Curse Rooms and Sacrifice Rooms wont destroy it, Taking a hit and activating Holy Mantle won't destroy it, Can be dropped in order to avoid breaking it, This trinket is automatically given to you after clearing 3 bosses without taking damage, Treasure Rooms are replaced with Red Treasure Rooms, which contain a deal with the devil in place of a regular item pedestal, If an item room has not yet been entered, it can be transformed to either a regular or Red Treasure Room by picking up or dropping this trinket before entering, Does not affect the mirrored treasure room in Downpour II, UNLOCK: Unlock this trinket by defeating Mother as Azazel, Every time you pick up a coin, you have a small chance to gain 1 bar of charge on your active item, The chance for this effect to happen is 1/6th of the value of the coin picked up, Can only activate once per coin collected, In Antibirth this trinket was called Electric Penny, UNLOCK: Unlock this trinket by donating to a battery beggar until he pays out with an item 5 times, While held, your familiars will now orbit around Isaac instead of following behind him, Activates your active item just before damage would be taken, It doesn't activate for free - the charges are used up as normal if this effect activates. It also doesn't do poison damage despite having the tagline 'toxic aura tears', * item room, treasure room, item room pool, brown, pink, purple, plant, Upon entering every 4th unexplored room, the Broken Watch will either slow down or speed up all enemies in the room, The slow effect is much more common than the speed up, * shop room pool, shop item pool, blue, grey, gray, smashed, clock, broken stop watch, broken stopwatch, A blue boomerang which can be thrown in a similar fashion to Mom's Knife, to stun any enemies it hits and deal damage, The damage dealt by the Boomerang is equal to double your tear damage, The boomerang can also be used to grab pickups and consumables from a distance, similar to the legend of zelda boomerang, The range of the boomerang is affected by range, with number one the distance is very short and makes the item a lot less effective, The Boomerang can be used to kill shopkeeper corpses, allowing you to farm their drops for coins, items, Steam Sale etc, REPENTANCE - Boomerang is now piercing, and has far less downtime between throwing it and being able to fire tears again, * shop room pool, shop item pool, crescent, moon, blue, grey, gray, * boss room pool, boss room item, grey, gray, punk, Decreases the size of Isaac, and your player hitbox, making you less likely to be hit, * boss room pool, boss room item, pro plus, tablet, medicine, white, * boss room pool, boss room item, grey, orange, family, picture, * boss room pool, boss room item, mushroom, fungi, fungus, Item Pool: Boss Room, Gold/Stone Chest, Key Beggar, * boss room pool, boss room item, brass, bronze, brown, gold, REPENTANCE - Also drops the Match Stick trinket, * boss room pool, boss room item, white, red, * boss room pool, boss room item, syringe, needle, grey, purple, pink, * boss room pool, boss room item, the lost item pool, dog, biscuit, brown, orange, A one-time use item which when used, will duplicate any pedestal items or consumables in the current room, If used in a shop, the duplicated items can be taken for free, If used on a trinket, another random trinket will spawn instead of a duplicate, If used in the Boss Rush, all the duplicates can be taken for free as well as one of the original items, If used in a Devil Room or Black Market, the duplicates can be taken for free, When used, copies the effect of the pill you are currently holding without consuming it, The charge time of this item depends on the quality of the pill you're holding, When used, has a 50% chance to drop one random type of coin (penny, nickel or dime), UNLOCK: Unlock this item by donating 33 coins to the Greed Donation Machine, UNLOCK: Keeper starts with this item after beating Isaac with Keeper, With this item, at the start of every room you will deal double your tear damage to the entire room in a poison effect, Enemies killed now also leave a pool of creep on the ground where they died. Based on the Steam Workshop mod created by Merlo. The second knife piece is on the second floor of the Mines. Beyond the womb floor, replaces all coin and key spawns with a random pickup as follows: Bomb - 26.6% chance. REPENTANCE - +0.2 Speed Up (Used to be -0.1 Speed before Repentance). After dealing enough damage it will eventually disappear, At full size the flame deals 6x your tear damage, scaling down to 3x at its smallest size, The chance to for each tear to become a flame is affected by your luck stat and at +10 Luck it will activate 50% of the time (starts at 8.33% at +0 Luck), Each tear now has a small chance (3.33%) to be a needle instead, which deals 3 times your tear damage, If a needle hits a non-boss enemy it will instantly kill it and will explode into a circle of 10 more needles, The 10 spawned needles will also deal 3 times your tear damage, but won't instantly kill enemies or explode into more needles, The chance to for each tear to become a needle is affected by your luck stat and at +15 Luck it will activate 50% of the time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lilith, *, black, syringe, injection, euthansia, dang, dan gheesling, dangheesling, dangDEB8, you piece, Upon entering a new room, Isaac will become camouflaged and enemies won't attack until you start firing tears, Camo Undies grants +0.5 speed while cloaked, When uncloaking, all nearby enemies take damage, and Isaac gains a brief tears + damage up, *, pink, purple, goggles underwear under wear, Any time a devil or angel room door opens after a boss, the other one will also spawn, The extra door will only spawn if a devil or angel room was randomly chosen to spawn already, After entering one of the doors, the other will disappear, If there isn't an available wall for the extra door to spawn on, only one door will spawn (i.e.

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